IJU Case Rep . Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low-dose methylprednisolone

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IJU Case Rep


. 2020 Oct 5;10.1002/iju5.12226.
doi: 10.1002/iju5.12226. Online ahead of print.
Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low-dose methylprednisolone


Ryo Tanaka ¹ , Yoichi Kakuta ¹ , Koichi Tsutahara ¹ , Masahiro Nakagawa ¹ , Naotsugu Ichimaru ² , Katsuhiko Sakaguchi ² , Taigo Kato ³ , Ryoichi Imamura ³ , Norio Nonomura ³ , Tetsuya Takao ¹



Affiliations

• PMID: 33230502
• PMCID: PMC7675346
• DOI: 10.1002/iju5.12226

Abstract

Introduction: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low-dose mPSL.
Case presentation: A 36-year-old man, who underwent living kidney transplantation 1.5 year prior, developed fever. After 10 days, he developed dyspnea, and his blood oxygen levels decreased. Computed tomography showed pulmonary ground-glass shadow on both lungs, and the coronavirus disease 2019 real-time polymerase chain reaction test was positive. After reducing the immunosuppressive agents, the C-reactive protein levels continued elevating, and the pulmonary shadow spread. Subsequently, low-dose methylprednisolone (40 mg/day) was administered for 4 days and his C-reactive protein and blood oxygen levels increased and improved, respectively. The coronavirus disease 2019 real-time polymerase chain reaction test was negative and the pulmonary shadow disappeared.
Conclusion: Low-dose methylprednisolone may prevent the development of severe coronavirus disease 2019.

Keywords: COVID‐19; immunosuppressive therapy; kidney transplantation; low‐dose methylprednisolone; solid organ transplant.