Cureus . Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation

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Cureus


. 2020 Oct 6;12(10):e10822.
doi: 10.7759/cureus.10822.
Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation


Rafael Salazar Sr ¹ , Alejandro Hallo ² , Sebastian Vasquez ¹ , Steffy Reinthaller ¹ , Juan Echeverria ¹



Affiliations

• PMID: 33173630
• PMCID: PMC7645293
• DOI: 10.7759/cureus.10822

Abstract

The number of patients with acute episodes of severe bronchospasm needing intubation and ventilatory support has increased rapidly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) pandemic. Although medical consensus upholds the use of ventilatory support in this pathology, its survival benefits remain unclear. To improve the outcomes and survival rates, a bundle of early respiratory therapy with a pharmacological rescue regimen was provided to four patients with bronchospasm secondary to COVID-19. This therapeutic approach successfully delayed the need for invasive mechanical ventilation for 48 hours and decreased the mortality rate in all cases.

Keywords: covid-19 management; covid-19 outbreak; invasive mechanical ventilation.