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J Transl Autoimmun . Why will it never be known if convalescent plasma is effective for COVID-19

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  • J Transl Autoimmun . Why will it never be known if convalescent plasma is effective for COVID-19


    J Transl Autoimmun


    . 2020 Nov 4;100069.
    doi: 10.1016/j.jtauto.2020.100069. Online ahead of print.
    Why will it never be known if convalescent plasma is effective for COVID-19


    Manuel Rojas 1 , Juan-Manuel Anaya 1 2



    Affiliations

    Abstract

    High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. However, none of the randomized controlled trials (RCTs) conducted so far have reached their primary endpoints. Herein we report that RCTs of CP disclose a high methodological variability in inclusion criteria, outcomes, appropriate selection of donors, dosage, concentration of neutralizing antibodies and times of transfusion. Therefore, at this time there is insufficient evidence to recommend for or against the use of CP as a treatment for COVID-19.

    Keywords: COVID-19; Clinical trials; Convalescent plasma; Coronavirus; Randomized; SARS-Cov-2.

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