Anesth Analg
. 2020 Oct 21.
doi: 10.1213/ANE.0000000000005292. Online ahead of print.
Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19
Jonathan H Chow 1 , Ashish K Khanna 2 3 , Shravan Kethireddy 4 , David Yamane 5 , Andrea Levine 6 , Amanda M Jackson 7 , Michael T McCurdy 7 , Ali Tabatabai 6 8 , Gagan Kumar 4 , Paul Park 9 , Ivy Benjenk 10 , Jay Menaker 8 11 , Nayab Ahmed 12 , Evan Glidewell 13 , Elizabeth Presutto 9 , Shannon Cain 14 , Naeha Haridasa 10 , Wesley Field 12 , Jacob G Fowler 13 , Duy Trinh 9 , Kathleen N Johnson 13 , Aman Kaur 12 , Amanda Lee 9 , Kyle Sebastian 13 , Allison Ulrich 9 , Salvador Pe?a 13 , Ross Carpenter 9 , Shruti Sudhakar 9 , Pushpinder Uppal 9 , Benjamin T Fedeles 9 , Aaron Sachs 9 , Layth Dahbour 9 , William Teeter 8 15 , Kenichi Tanaka 16 , Samuel M Galvagno 17 8 , Daniel L Herr 7 , Thomas M Scalea 8 11 , Michael A Mazzeffi 17 16
Affiliations
- PMID: 33093359
- DOI: 10.1213/ANE.0000000000005292
Abstract
Background: Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.
Methods: A retrospective, observational cohort study of adult patients admitted with COVID-19 to multiple hospitals in the United States between March 2020 and July 2020 was performed. The primary outcome was the need for mechanical ventilation. Secondary outcomes were ICU admission and in-hospital mortality. Adjusted hazard ratios for study outcomes were calculated using Cox proportional hazards models after adjustment for the effects of demographics and co-morbid conditions.
Results: Four hundred twelve patients were included in the study. Three hundred fourteen patients (76.3%) did not receive aspirin, while 98 patients (23.7%) received aspirin within 24 hours of admission or 7 days prior to admission. Aspirin use had a crude association with less mechanical ventilation (35.7% aspirin vs. 48.4% non-aspirin, p=0.03) and ICU admission (38.8% aspirin vs. 51.0% non-aspirin, p=0.04), but no crude association with in-hospital mortality (26.5% aspirin vs. 23.2% non-aspirin, p=0.51). After adjusting for 8 confounding variables, aspirin use was independently associated with decreased risk of mechanical ventilation (adjusted HR 0.56, 95% CI 0.37-0.85, p=0.007), ICU admission (adjusted HR 0.57, 95% CI 0.38-0.85, p=0.005), and in-hospital mortality (adjusted HR 0.53, 95% CI 0.31-0.90, p=0.02). There were no differences in major bleeding (p=0.69) or overt thrombosis (p=0.82) between aspirin users and non-aspirin users.
Conclusions: Aspirin use may be associated with improved outcomes in hospitalized COVID-19 patients. However, a sufficiently powered randomized controlled trial is needed to assess whether a causal relationship exists between aspirin use and reduced lung injury and mortality in COVID-19 patients.