J Infect Dis . Associations between genetically predicted protein levels and COVID-19 severity

[tetano]

J Infect Dis


. 2020 Oct 21;jiaa660.
doi: 10.1093/infdis/jiaa660. Online ahead of print.
Associations between genetically predicted protein levels and COVID-19 severity


Jingjing Zhu ¹ , Chong Wu ² , Lang Wu ¹



Affiliations

• PMID: 33083826
• DOI: 10.1093/infdis/jiaa660

Abstract

It is critical to identify potential causal targets for SARS-coronavirus 2, which may guide drug repurposing options. We assessed the associations between genetically predicted protein levels and COVID-19 severity. Leveraging data from The COVID-19 host genetics initiative comparing 6,492 hospitalized COVID-19 patients and 1,012,809 controls, we identified 18 proteins with genetically predicted levels to be associated with COVID-19 severity at a false discovery rate of <0.05, including 12 that showed an association even after Bonferroni correction. Of the 18 proteins, six showed positive associations and 12 showed inverse associations. In conclusion, we identified 18 candidate proteins for COVID-19 severity.

Keywords: COVID-19 severity; Proteins; genetic instruments.