Am J Gastroenterol . Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice - FluTrackers News and Information

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Am J Gastroenterol . Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice

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tetano started a topic Am J Gastroenterol . Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice

August 30, 2020, 04:33 AM

Am J Gastroenterol . Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice

Am J Gastroenterol

. 2020 Aug 27.
doi: 10.14309/ajg.0000000000000828. Online ahead of print.
Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice

Clementine Levy¹, Guillaume Lassailly², Erika Parmentier¹, Thibault Duburcq¹, Philippe Mathurin², Julien Poissy¹

Affiliations
PMID: 32858566

DOI: 10.14309/ajg.0000000000000828

Abstract

Introduction: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus.
Methods: This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group.
Results: Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%).
Discussion: Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus.

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