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Acta Pharmacol Sin . Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

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  • Acta Pharmacol Sin . Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19


    Acta Pharmacol Sin


    . 2020 Aug 3.
    doi: 10.1038/s41401-020-0485-4. Online ahead of print.
    Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19


    Yuan Huang 1 , Chan Yang 1 , Xin-Feng Xu 1 , Wei Xu 2 , Shu-Wen Liu 3 4



    Affiliations

    Abstract

    Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.

    Keywords: SARS-CoV-2 virus; antibodies; antivirus drugs; fusion inhibitors; host proteases inhibitors; spike protein.

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