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Crit Care Explor . Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome

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  • Crit Care Explor . Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome


    Crit Care Explor


    . 2020 Jun 15;2(6):e0143.
    doi: 10.1097/CCE.0000000000000143. eCollection 2020 Jun.
    Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome


    Amit Chopra 1 , Hau C Chieng 1 , Adam Austin 1 , Anupama Tiwari 1 , Swati Mehta 2 , Amit Nautiyal 1 , Ali Hani Al-Tarbsheh 2 , Esha Jain 2 , Paul J Feustel 3 , Boris Shkolnik 1 , Ariel Jaitovich 1



    Affiliations

    Abstract

    Objectives: To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not.
    Design: Retrospective analysis.
    Setting: Intensive care setting.
    Patients: All adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome.
    Interventions: None.
    Measurements and main results: Cohort was divided into two groups based on corticosteroid administration. The primary outcome variable was ventilator-free days at day 28. Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30. Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed. Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10.2; median, 7 [interquartile range, 0-22.3] vs mean, 4.7; median, 0 [interquartile range, 0-11]; p = 0.01).There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30).
    Conclusions: Among mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30.

    Keywords: acute respiratory distress syndrome; corticosteroids; mechanical ventilator; outcome; severe acute respiratory syndrome coronavirus 2.

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