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Front Microbiol . Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection

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  • Front Microbiol . Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection


    Front Microbiol


    . 2020 Jun 9;11:1388.
    doi: 10.3389/fmicb.2020.01388. eCollection 2020.
    Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection


    Li-Hong He 1 2 3 , Long-Fei Ren 1 2 3 , Jun-Feng Li 4 , Yong-Na Wu 3 , Xun Li 1 2 3 , Lei Zhang 1 2 3



    Affiliations

    Abstract

    The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide, seriously endangering human health. In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. It is known that a healthy intestinal flora is closely related to the maintenance of pulmonary and systemic health by regulating the host immune homeostasis. Role of the "gut-lung axis" has also been well-articulated. This review provides a novel suggestion that intestinal flora may be one of the mediators of the gastrointestinal responses and abnormal immune responses in hosts caused by SARS-CoV-2; improving the composition of intestinal flora and the proportion of its metabolites through probiotics, and personalized diet could be a potential strategy to prevent and treat COVID-19. More clinical and evidence-based medical trials may be initiated to determine the strategy.

    Keywords: COVID-19; SARS-CoV-2; SCFAs; gut-lung axis; immunity; intestinal flora.

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