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iScience Mitigating Coronavirus-Induced Acute Respiratory Distress Syndrome by Radiotherapy

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  • iScience Mitigating Coronavirus-Induced Acute Respiratory Distress Syndrome by Radiotherapy


    iScience


    . 2020 May 30;23(6):101215.
    doi: 10.1016/j.isci.2020.101215. Online ahead of print.
    Mitigating Coronavirus-Induced Acute Respiratory Distress Syndrome by Radiotherapy


    Jian Jian Li 1



    Affiliations

    Abstract

    The acute respiratory distress syndrome (ARDS) induced by SARS-CoV-2-mediated cytokine storm (CS) in lungs leads to the high mortality in COVID-19 patients. To reduce ARDS, an ideal approach is to diminish virus loading by activating immune cells for CS prevention or to suppress the overactive cytokine-releasing immune cells for CS inhibition. Here, a potential radiation-mediated CS regulation is raised by reevaluating the radiation-mediated pneumonia control in the 1920s, with the following latent advantages of lung radiotherapy (LR) in treatment of COVID-19: (1) radiation accesses poorly circulated tissue more efficiently than blood-delivered medications; (2) low-dose radiation (LDR)-mediated metabolic rewiring and immune cell activation inhibit virus loading; (3) pre-consumption of immune reserves by LDR decreases CS severity; (4) higherdose radiation (HDR) within lung-tolerable doses relieves CS by eliminating in situ overactive cytokine-releasing cells. Thus, LDR and HDR or combined with antiviral and life-supporting modalities may mitigate SARS-CoV-2 and other virus-mediated ARDS.

    Keywords: Health Sciences; Immunology; Therapy.

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