Mem Inst Oswaldo Cruz Coagulation Modifiers Targeting SARS-CoV-2 Main Protease Mpro for COVID-19 Treatment: An in Silico Approach

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Mem Inst Oswaldo Cruz


. 2020;115:e200179.
doi: 10.1590/0074-02760200179. Epub 2020 Jun 1.
Coagulation Modifiers Targeting SARS-CoV-2 Main Protease Mpro for COVID-19 Treatment: An in Silico Approach


?sis Venturi Biembengut ¹ , Tatiana de Arruda Campos Brasil de Souza ¹



Affiliations

• PMID: 32490889
• DOI: 10.1590/0074-02760200179

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applicability of commercially approved drugs to treat coronavirus disease-19 (COVID-19). We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV-2 Mpro and human coagulation factors thrombin and Factor Xa. Further in vitro and in vivo analysis are needed to corroborate these results.