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Ann Clin Microbiol Antimicrob Ivermectin, a New Candidate Therapeutic Against SARS-CoV-2/COVID-19
Ivermectin exerts broad-spectrum antiviral activity against several animal and human viruses, including both RNA and DNA viruses.
The antiviral potential of ivermectin against various viruses is mediated via the targeting of the following: importin α/β-mediated nuclear transport of HIV-1 integrase and NS5 polymerase; NS3 helicase; nuclear import of UL42; and nuclear localization signal-mediated nuclear import of Cap.
As SARS-CoV-2 is an RNA virus, the antiviral activity of ivermectin may be mediated through the inhibition of importin α/β-mediated nuclear transport of viral proteins.
The clinical efficacy and utility of ivermectin in SARS-CoV-2-infected patients are unpredictable at this stage, as we are dealing with a completely novel virus.
?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
Richard Horton, Editor-in-Chief The Lancet
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