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Clin Immunol. Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19

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  • Clin Immunol. Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19


    Clin Immunol. 2020 May 13:108464. doi: 10.1016/j.clim.2020.108464. [Epub ahead of print]
    Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.


    Omarjee L1,2, Janin A3, Perrot F4, Laviolle B5, Meilhac O6,7, Mahe G5.

    Author information




    KEYWORDS:

    CD, Cluster of Differentiation; COVID-19, Corona-Virus-Disease-2019; CTLA-4, Cytotoxic T Lymphocyte Associated protein 4; G-CSF, Granulocyte Colony Stimulating factor; IFN-γ, Interferon gamma; IL, Interleukin; IP-10, Interferon gamma-induced Protein 10; MCP-1, Monocyte Chemoattractant Protein 1; MIP-1α, Macrophage Inflammatory Protein 1 alpha; NF-κB, Nuclear Factor-kappa B; NLRP3, Nucleotide-binding oligomerization domain (NOD)-Like Receptor family, Pyrin domain containing 3; PD-1, Programmed cell Death 1; ROS, Reactive Oxygen Species; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; TIGIT, T-cell Immunoreceptor with Ig and ITIM (Immunoreceptor Tyrosine-based Inhibition Motif) domains; TLR, Toll Like Receptor; TNFα, Tumor Necrosis Factor alpha; Tim-3, T-cell immunoglobulin mucin-3; mTOR, mammalian Target Of Rapamycin


    PMID:32405269PMCID:PMC7217787DOI:10.1016/j.clim.2020.108464

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