iScience. The MERS-CoV receptor DPP4 as a candidate binding target of the SARS-CoV-2 spike

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iScience. 2020 May 13:101160. doi: 10.1016/j.isci.2020.101160. [Epub ahead of print]
The MERS-CoV receptor DPP4 as a candidate binding target of the SARS-CoV-2 spike.


Li Y¹, Zhang Z¹, Yang L^2,3,4, Lian X¹, Xie Y^2,3, Li S^2,3, Xin S^2,3,4, Cao P², Lu J^2,3,4.

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Abstract

The ongoing outbreak of the novel coronavirus pneumonia COVID-19 has caused great number of cases and deaths, but our understanding about the pathogen SARS-CoV-2 remains largely unclear. The attachment of the virus with the cell-surface receptor and a co-factor is the first step for the infection. Here, bioinformatics approaches combining human-virus protein interaction prediction and protein docking based on crystal structures have revealed the high affinity between human dipeptidyl peptidase 4 (DPP4) and the spike (S) receptor-binding domain of SARS-CoV-2. Intriguingly, the crucial binding residues of DPP4 are identical to those as bound to the MERS-CoV-S. Moreover, E484 insertion and adjacent substitutions should be most essential for this DPP4-binding ability acquirement of SARS-CoV-2-S compared with SARS-CoV-S. This potential utilization of DPP4 as a binding target for SARS-CoV-2 may offer novel insight into the viral pathogenesis, and help the surveillance and therapeutics strategy for meeting the challenge of COVID-19.
? 2020 The Author(s).



PMID:32405622PMCID:PMC7219414DOI:10.1016/j.isci.2020.101160