Zhejiang Da Xue Xue Bao Yi Xue Ban. Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab

[tetano]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):227-231.
[Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab].


[Article in Chinese]

Luo S¹, Yang L², Wang C¹, Liu C³, Li D⁴.

Author information




Abstract

OBJECTIVE:

To observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19).
METHODS:

Six patients with severe COVID-19 admitted in First Affiliated Hospital of Bengbu Medical College from January 25 to February 25, 2020. Three patients were treated with plasma exchange and three patients were treated with tocilizumab. The effect on excessive inflammatory reaction of plasma exchange and tocilizumab was observed.
RESULTS:

The C-reactive protein (CRP) and IL-6 levels were significantly decreased and the lymphocyte and prothrombin time were improved in 3 patients after treatment with plasma exchange; while inflammation level was not significantly decreased, and lymphocyte and prothrombin time did not improve in 3 patients treated with tocilizumab.
CONCLUSIONS:

For severe COVID-19 patients with strong inflammatory reaction, plasma exchange may be preferred.



PMID:32391669