Clin Pharmacol Ther. Off-Label Therapies for COVID-19-Are We All In This Together? - FluTrackers News and Information

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Clin Pharmacol Ther. Off-Label Therapies for COVID-19-Are We All In This Together?

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tetano

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Clin Pharmacol Ther. Off-Label Therapies for COVID-19-Are We All In This Together?

April 22, 2020, 01:27 PM

Clin Pharmacol Ther. 2020 Apr 20. doi: 10.1002/cpt.1862. [Epub ahead of print]
Off-Label Therapies for COVID-19-Are We All In This Together?

Alpern JD^1,^2,³, Gertner E^1,^4,³.

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Abstract

SARS-CoV-2 continues to spread rapidly outside of mainland China. As of April 6, there are over 300,000 cases and 10,000 deaths in the US. Effective therapies for the novel Coronavirus are urgently needed and over 200 clinical trials are now underway across the globe. Recognizing the need for robust randomized control trials, the World Health Organization (WHO) recently organized a multinational randomized trial-the SOLIDARITY trial-to study the effect of drugs that have been identified as promising based on in-vitro data and the early clinical experience with COVID-19: Remdesivir, lopinavir and ritonavir; lopinavir and ritonavir + interferon; and chloroquine or hydroxychloroquine.
This article is protected by copyright. All rights reserved.

KEYWORDS:

FDA; ethics; public policy

PMID:32311763DOI:10.1002/cpt.1862

Tags: None

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