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J Infect. Cytokine Storm in COVID-19 and Treatment

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  • J Infect. Cytokine Storm in COVID-19 and Treatment


    J Infect. 2020 Apr 10. pii: S0163-4453(20)30165-1. doi: 10.1016/j.jinf.2020.03.037. [Epub ahead of print]
    Cytokine Storm in COVID-19 and Treatment.


    Ye Q1, Wang B1, Mao J2.

    Author information




    Abstract

    Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
    Copyright ? 2020 Elsevier Ltd. All rights reserved.



    KEYWORDS:

    2019-nCoV; Coronavirus; Cytokine storm; Immunomodulation; SARS-CoV-2


    PMID:32283152DOI:10.1016/j.jinf.2020.03.037

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