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Biosci Trends. Macrolide treatment for COVID-19: Will this be the way forward?

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  • Biosci Trends. Macrolide treatment for COVID-19: Will this be the way forward?


    Biosci Trends. 2020 Apr 5. doi: 10.5582/bst.2020.03058. [Epub ahead of print]
    Macrolide treatment for COVID-19: Will this be the way forward?


    Ohe M1, Shida H1, Jodo S1, Kusunoki Y1, Seki M1, Furuya K1, Goudarzi H2.

    Author information




    Abstract

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Lately, the anti-viral effects of macrolides have attracted considerable attention. Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. We believe that treatments with macrolides alone or in combination with other drugs are promising and open the possibility of an international strategy to fight this emerging viral infection.



    KEYWORDS:

    COVID-19; SARS-CoV-2; macrolide


    PMID:32249257DOI:10.5582/bst.2020.03058
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