Int J Biol Sci. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2

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Int J Biol Sci. 2020 Mar 15;16(10):1718-1723. doi: 10.7150/ijbs.45123. eCollection 2020.
Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2.


Zhou G^1,2, Zhao Q^1,2.

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Abstract

A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.
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KEYWORDS:

COVID-19; Neutralizing antibody; SARS-CoV-2; severe acute respiratory syndrome


PMID:32226289PMCID:PMC7098029DOI:10.7150/ijbs.45123