China conducting clinical trial of intravenous vitamin C for coronavirus patients

[Gert van der Hoek]

Brief Summary:

2019 new coronavirus (2019-nCoV) infected pneumonia, namely severe acute respiratory infection (SARI) has caused global concern and emergency. There is a lack of effective targeted antiviral drugs, and symptomatic supportive treatment is still the current main treatment for SARI.

Vitamin C is significant to human body and plays a role in reducing inflammatory response and preventing common cold. In addtion, a few studies have shown that vitamin C deficiency is related to the increased risk and severity of influenza infections.

We hypothize that Vitamin C infusion can help improve the prognosis of patients with SARI. Therefore, it is necessary to study the clinical efficacy and safety of vitamin C for the clinical management of SARI through randomized controlled trials during the current epidemic of SARI.

Estimated Study Start Date :	February 10, 2020
Estimated Primary Completion Date :	September 30, 2020
Estimated Study Completion Date :	September 30, 2020

[Gert van der Hoek]

Three Intravenous Vitamin C Research Studies Approved for Treating COVID-19

by Andrew W. Saul, Editor


(OMNS February 21, 2020) Intravenous vitamin C is already being employed in China against COVID-19 coronavirus. I am receiving regular updates because I am part of the Medical and Scientific Advisory Board to the International Intravenous Vitamin C China Epidemic Medical Support Team. Its director is Richard Z. Cheng, MD, PhD; associate director is Hong Zhang, PhD. Among other team members are Qi Chen, PhD (Associate Professor, Kansas University Medical School); Jeanne Drisko, MD (Professor, University of Kansas Medical School); Thomas E. Levy, MD, JD; and Atsuo Yanagisawa, MD, PhD. (Professor, Kyorin University, Tokyo). To read the treatment protocol information in English: http://orthomolecular.org/resources/omns/v16n07.shtml (Protocol in Chinese at http://www.doctoryourself.com/Corona...C_Protocol.pdf


Direct report from China

OMNS Chinese edition editor Dr. Richard Cheng is reporting from China about the first approved study of 12,000 to 24,000 mg/day of vitamin C by IV. The doctor also specifically calls for immediate use of vitamin C for prevention of coronavirus (COVID-19). https://www.youtube.com/watch?v=TC0SO9KDG7U

A second clinical trial of intravenous vitamin C was announced in China on Feb. 13th. In this second study, says Dr. Cheng, "They plan to give 6,000 mg/day and 12,000 mg/day per day for moderate and severe cases. We are also communicating with other hospitals about starting more intravenous vitamin C clinical studies. We would like to see oral vitamin C included in these studies, as the oral forms can be applied to more patients and at home." Additional information at http://orthomolecular.org/resources/omns/v16n11.shtml

And on Feb 21, 2020, announcement has been made of a third research trial now approved for intravenous vitamin C for COVID-19. https://www.youtube.com/watch?v=VMDX...ature=youtu.be

Dr. Cheng, who is a US board-certified specialist in anti-aging medicine, adds: "Vitamin C is very promising for prevention, and especially important to treat dying patients when there is no better treatment. Over 2,000 people have died of the COIV-19 outbreak and yet I have not seen or heard large dose intravenous vitamin C being used in any of the cases. The current sole focus on vaccine and specific antiviral drugs for epidemics is misplaced."

He adds that: "Early and sufficiently large doses of intravenous vitamin C are critical. Vitamin C is not only a prototypical antioxidant, but also involved in virus killing and prevention of viral replication. The significance of large dose intravenous vitamin C is not just at antiviral level. It is acute respiratory distress syndrome (ARDS) that kills most people from coronaviral pandemics (SARS, MERS and now NCP). ARDS is a common final pathway leading to death.

"We therefore call for a worldwide discussion and debate on this topic."

READ MORE

Vol. 16, No. 04	January 26, 2020	Vitamin C Protects Against Coronavirus
Vol. 16, No. 06	January 30, 2020	Nutritional Treatment of Coronavirus
Vol. 16, No. 07	February 2, 2020	Hospital-based Intravenous Vitamin C Treatment for Coronavirus and Related Illnesses
Vol. 16, No. 09	February 10, 2020	VITAMIN C AND ITS APPLICATION TO THE TREATMENT OF nCoV CORONAVIRUS: How Vitamin C Reduces Severity and Deaths from Serious Viral Respiratory Diseases
Vol. 16, No. 10	February 13, 2020	Coronavirus Patients in China to be Treated with High-Dose Vitamin C
Vol. 16, No. 11	February 16, 2020	Early Large Dose Intravenous Vitamin C is the Treatment of Choice for 2019-nCov Pneumonia

[Emily]

One of the Covid-19 patients said the hospital he was in wouldn't allow him to take any vitamin C. He looked very distressed by that.

Here are a couple of research articles that seem related, but not about Covid-19 treatment specifically.

https://academic.oup.com/jac/article/52/6/1049/731701

http://www.mv.helsinki.fi/home/hemila/CC/Sabiston_1974_ch.pdf