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Crit Care Sci
. 2024 Dec 20:36:e202400251en.
doi: 10.62675/2965-2774.20240251-en. eCollection 2024. Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry
[Article in English, Portuguese]
Safira A Wortel 1 2 , Ferishta Bakhshi-Raiez 1 2 , Ameen Abu-Hanna 1 , Dave A Dongelmans 2 3 , Nicolette F de Keizer 1 2 ; Dutch COVID-19 Research Consortium 4 ; Aletta Houwink 4 , Allard Dijkhuizen 5 , Annelies Draisma 6 , Annemiek Rijkeboer 7 , Arjan Cloïn 8 , Arthur de Meijer 9 , Auke Reidinga 10 , Barbara Festen-Spanjer 11 , Bas van Bussel 12 , Bob Eikemans 13 , Cretièn Jacobs 14 , David Moolenaar 10 , Dharmanand Ramnarain 15 , Dick Koning 16 , Dirk Boer 17 , Dirk Verbiest 18 , Eline van Slobbe-Bijlsma 19 , Ellen van Koppen 20 , Els Rengers 21 , Erik van Driel 22 , Eva Verweij 23 , Freya van Iersel 24 , Gert Brunnekreef 25 , Hans Kieft 26 , Herman Kreeftenberg 27 , Ilanit Hené 28 , Inge Janssen 29 , Ionana Drogt 30 , Iwan van der Horst 12 , Jan Jaap Spijkstra 31 , Jan Rozendaal 32 , Jannet Mehagnoul-Schipper 33 , Jelle Epker Erasmus 34 , Jessica Holtkamp 35 , Johan Lutisan 36 , Jos van Oers 37 , Judith Lens 38 , Laura van Gulik 39 , Lettie van den Berg 40 , Louise Urlings-Strop 41 , Lyuba Georgieva 42 , Maarten van Lieshout 43 , Marga Hoogendoorn 26 , Marissa Vrolijk-de Mos 44 , Mart de Graaff 45 , Martha de Bruin 46 , Martijn Hoeksema 47 , Martijn van Tellingen 48 , Michel Barnas 49 , Michiel Erkamp 50 , Niels Gritters 51 , Nuray Kusadasi 52 , Paul Elbers 31 , Peter Koetsier 53 , Peter Spronk 54 , Peter van der Voort 55 , Ralph Pruijsten 56 , Remko de Jong 57 , Robert-Jan Bosman 58 , Ronald Wesselink 45 , Ronny Schnabel 12 , Roy van den Berg 15 , Ruud de Waal 59 , Sesmu Arbous 60 , Silvia Knape 61 , Stefaan Hendriks 62 , Tim Frenzel 63 , Tom Dormans 64 , Tom Rijpstra 59 , Vera Silderhuis 65 , Wouter de Ruijter 66
Affiliations
in English, Portuguese
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge.
Results: We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results.
Conclusion: For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.
. 2024 Dec 20:36:e202400251en.
doi: 10.62675/2965-2774.20240251-en. eCollection 2024. Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry
[Article in English, Portuguese]
Safira A Wortel 1 2 , Ferishta Bakhshi-Raiez 1 2 , Ameen Abu-Hanna 1 , Dave A Dongelmans 2 3 , Nicolette F de Keizer 1 2 ; Dutch COVID-19 Research Consortium 4 ; Aletta Houwink 4 , Allard Dijkhuizen 5 , Annelies Draisma 6 , Annemiek Rijkeboer 7 , Arjan Cloïn 8 , Arthur de Meijer 9 , Auke Reidinga 10 , Barbara Festen-Spanjer 11 , Bas van Bussel 12 , Bob Eikemans 13 , Cretièn Jacobs 14 , David Moolenaar 10 , Dharmanand Ramnarain 15 , Dick Koning 16 , Dirk Boer 17 , Dirk Verbiest 18 , Eline van Slobbe-Bijlsma 19 , Ellen van Koppen 20 , Els Rengers 21 , Erik van Driel 22 , Eva Verweij 23 , Freya van Iersel 24 , Gert Brunnekreef 25 , Hans Kieft 26 , Herman Kreeftenberg 27 , Ilanit Hené 28 , Inge Janssen 29 , Ionana Drogt 30 , Iwan van der Horst 12 , Jan Jaap Spijkstra 31 , Jan Rozendaal 32 , Jannet Mehagnoul-Schipper 33 , Jelle Epker Erasmus 34 , Jessica Holtkamp 35 , Johan Lutisan 36 , Jos van Oers 37 , Judith Lens 38 , Laura van Gulik 39 , Lettie van den Berg 40 , Louise Urlings-Strop 41 , Lyuba Georgieva 42 , Maarten van Lieshout 43 , Marga Hoogendoorn 26 , Marissa Vrolijk-de Mos 44 , Mart de Graaff 45 , Martha de Bruin 46 , Martijn Hoeksema 47 , Martijn van Tellingen 48 , Michel Barnas 49 , Michiel Erkamp 50 , Niels Gritters 51 , Nuray Kusadasi 52 , Paul Elbers 31 , Peter Koetsier 53 , Peter Spronk 54 , Peter van der Voort 55 , Ralph Pruijsten 56 , Remko de Jong 57 , Robert-Jan Bosman 58 , Ronald Wesselink 45 , Ronny Schnabel 12 , Roy van den Berg 15 , Ruud de Waal 59 , Sesmu Arbous 60 , Silvia Knape 61 , Stefaan Hendriks 62 , Tim Frenzel 63 , Tom Dormans 64 , Tom Rijpstra 59 , Vera Silderhuis 65 , Wouter de Ruijter 66
Affiliations
- PMID: 39775432
- PMCID: PMC11463994
- DOI: 10.62675/2965-2774.20240251-en
in English, Portuguese
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge.
Results: We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results.
Conclusion: For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.