Announcement

Collapse
No announcement yet.

Nat Commun . A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Nat Commun . A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2


    Nat Commun


    . 2020 Aug 25;11(1):4252.
    doi: 10.1038/s41467-020-17986-9.
    A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2


    Hanjun Zhao 1 2 3 , Kelvin K W To 1 2 3 4 5 , Kong-**** Sze 1 2 , Timothy Tin-Mong Yung 2 3 , Mingjie Bian 6 , Hoiyan Lam 2 3 , Man Lung Yeung 1 2 3 5 , Cun Li 2 3 , Hin Chu 1 2 3 , Kwok-Yung Yuen 7 8 9 10 11



    Affiliations

    Abstract

    The 2019 novel respiratory virus (SARS-CoV-2) causes COVID-19 with rapid global socioeconomic disruptions and disease burden to healthcare. The COVID-19 and previous emerging virus outbreaks highlight the urgent need for broad-spectrum antivirals. Here, we show that a defensin-like peptide P9R exhibited potent antiviral activity against pH-dependent viruses that require endosomal acidification for virus infection, including the enveloped pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), and the non-enveloped rhinovirus. P9R can significantly protect mice from lethal challenge by A(H1N1)pdm09 virus and shows low possibility to cause drug-resistant virus. Mechanistic studies indicate that the antiviral activity of P9R depends on the direct binding to viruses and the inhibition of virus-host endosomal acidification, which provides a proof of concept that virus-binding alkaline peptides can broadly inhibit pH-dependent viruses. These results suggest that the dual-functional virus- and host-targeting P9R can be a promising candidate for combating pH-dependent respiratory viruses.


Working...
X