The Effect of a Lipopolysaccharide from Rhodobacter capsulatus PG on Inflammation Caused by Various Influenza Strains

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Acta Naturae. 2019 Jul-Sep;11(3):46-55. doi: 10.32607/20758251-2019-11-3-46-55. The Effect of a Lipopolysaccharide from Rhodobacter capsulatus PG on Inflammation Caused by Various Influenza Strains.

Zubova SV¹, Vorovich MF^2,3, Gambaryan AS², Ishmukhametov AA^2,3, Grachev SV^1,3, Prokhorenko IR¹.
Author information

1 Institute of Basic Biological Problems of RAS, FRC PSCBR RAS, Science Ave. 3, Pushchino, Moscow, 142290, Russia. 2 FGBNU Federal Scientific Center of Research and Development of Immunobiological Preparations named M.P. Chumakov of RAS, pos. Institute of Poliomyelitis, Kievskoye Highway, 27th km, 8/1, Moscow Region, 142782, Russia. 3 GAOUVO First Moscow State Medical University named I.M. Sechenov of Russia Health Ministry, Trubetskaya Str. 8, Moscow, 119811, Russia.

Abstract

The development of a specific inflammation in mice that had been infected by two influenza virus strains, A/chicken/Kurgan/5/2005 (H5N1) and A/Hamburg/2009 MA (H1N1), was studied. We investigated the effect of a non-toxic lipopolysaccharide from Rhodobacter capsulatus PG on the survival and body weight of the mice, production of IgG antibodies, and the induction of pro- and anti-inflammatory cytokines in blood serum. The administration of the R. capsulatus PG lipopolysaccharide was shown to induce interferon-β synthesis, both in healthy and influenza A virus-infected mice, and to promote production of antiviral antibodies in the blood of the influenza-infected animals.
Copyright ? 2019 National Research University Higher School of Economics.


KEYWORDS:

H1N1; H5N1; Rhodobacter capsulatus PG lipopolysaccharide; antiviral antibodies; cytokines; influenza virus; mice

PMID: 31720016 PMCID: PMC6826150 DOI: 10.32607/20758251-2019-11-3-46-55