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Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities

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  • Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities

    J Asian Nat Prod Res. 2019 Aug 1:1-6. doi: 10.1080/10286020.2019.1645132. [Epub ahead of print]
    Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities.

    Yin ZK1, Feng ZM1, Jiang JS1, Zhang X1, Zhang PC1, Yang YN1.
    Author information

    Abstract

    Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza. Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC50 = 0.67 μM) and oseltamivir (IC50 = 2.01 μM) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC50 values of 11.11 and 8.62 μM, respectively.


    KEYWORDS:

    ; Labiatae; antiviral activity; isolation and purification; structure elucidation; tanshinone diterpene derivatives

    PMID: 31368354 DOI: 10.1080/10286020.2019.1645132
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