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Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors

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  • Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors

    J Med Chem. 2019 Jun 28. doi: 10.1021/acs.jmedchem.9b00303. [Epub ahead of print]
    Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors.

    Lu W1, Du W2, Somovilla VJ1, Yu G1, Haksar D1, de Vries E2, Boons GJ1, de Vries RP1, de Haan CAM2, Pieters RJ1.
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    Abstract

    Multivalent carbohydrate-based ligands were synthesized and evaluated as inhibitors of the adhesion protein HA of the influenza A virus (IAV). HA relies on multivalency for strong viral adhesion. While viral adhesion inhibition by large polymeric molecules has proven viable, limited success was reached for smaller multivalent compounds. By linking of sialylated LAcNAc units to di- and trivalent scaffolds, inhibitors were obtained with an up to 428-fold enhanced inhibition in various assays.


    PMID: 31251606 DOI: 10.1021/acs.jmedchem.9b00303

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