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J Food Drug Anal. 2018 Jul;26(3):1015-1023. doi: 10.1016/j.jfda.2017.12.006. Epub 2018 Feb 2.
Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection.
Richart SM1, Li YL2, Mizushina Y3, Chang YY4, Chung TY5, Chen GH5, Tzen JT5, Shia KS6, Hsu WL7.
Author information
Abstract
Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
KEYWORDS:
Antiviral; Curcumin; Haemagglutinin; Influenza virus; Synergic
PMID: 29976394 DOI: 10.1016/j.jfda.2017.12.006
Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection.
Richart SM1, Li YL2, Mizushina Y3, Chang YY4, Chung TY5, Chen GH5, Tzen JT5, Shia KS6, Hsu WL7.
Author information
Abstract
Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
KEYWORDS:
Antiviral; Curcumin; Haemagglutinin; Influenza virus; Synergic
PMID: 29976394 DOI: 10.1016/j.jfda.2017.12.006