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Angew Chem Int Ed Engl. 1998 Jun 19;37(11):1524-1528. doi: 10.1002/(SICI)1521-3773(19980619)37:11<1524::AID-ANIE1524>3.0.CO;2-D.
A Lysoganglioside/Poly-L-glutamic Acid Conjugate as a Picomolar Inhibitor of Influenza Hemagglutinin.
Kamitakahara H1, Suzuki T2, Nishigori N2, Suzuki Y2, Kanie O1, Wong CH1.
Author information
Abstract
Based on the principle of a multivalent interaction, the amphiphilic polymer 1, present in solution as an aggregate (see below right), is able to inhibit infection with the influenza virus. After recognition of a specific sialyllactose epitope through hemaglutinin (HA) on the virus surface, the sphingosine residues and the fluorescent tag form a stable complex with HA through hydrophobic interactions. Polymer 1 shows in vitro inhibitory activity 106 -fold greater than that of sialyllactose. PGA=polyglutamic acid.
KEYWORDS:
Amphiphiles; Gangliosides; Molecular recognition; Receptors; Sialic acids
PMID: 29710929 DOI: 10.1002/(SICI)1521-3773(19980619)37:11<1524::AID-ANIE1524>3.0.CO;2-D
A Lysoganglioside/Poly-L-glutamic Acid Conjugate as a Picomolar Inhibitor of Influenza Hemagglutinin.
Kamitakahara H1, Suzuki T2, Nishigori N2, Suzuki Y2, Kanie O1, Wong CH1.
Author information
Abstract
Based on the principle of a multivalent interaction, the amphiphilic polymer 1, present in solution as an aggregate (see below right), is able to inhibit infection with the influenza virus. After recognition of a specific sialyllactose epitope through hemaglutinin (HA) on the virus surface, the sphingosine residues and the fluorescent tag form a stable complex with HA through hydrophobic interactions. Polymer 1 shows in vitro inhibitory activity 106 -fold greater than that of sialyllactose. PGA=polyglutamic acid.
KEYWORDS:
Amphiphiles; Gangliosides; Molecular recognition; Receptors; Sialic acids
PMID: 29710929 DOI: 10.1002/(SICI)1521-3773(19980619)37:11<1524::AID-ANIE1524>3.0.CO;2-D