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Biochem Biophys Res Commun. 2017 Sep 30. pii: S0006-291X(17)31957-5. doi: 10.1016/j.bbrc.2017.09.167. [Epub ahead of print]
Oral administration of Euglena gracilis Z and its carbohydrate storage substance provides survival protection against influenza virus infection in mice.
Nakashima A1, Suzuki K1, Asayama Y1, Konno M2, Saito K2, Yamazaki N2, Takimoto H3.
Author information
Abstract
Euglena gracilis Z is a micro-algae that is used as a food or nutritional supplement. Paramylon, the carbohydrate storage substance of Euglena gracilis Z has β-1, 3-glucan structure. Euglena gracilis Z and paramylon are reported to affect the immune system. In this study, we investigated the protective effects of Euglena gracilis Z and paramylon against influenza virus infection in mice. Euglena gracilis Z and paramylon were administered to mice as a 2% dietary mixture ad libitum. At 2 weeks after initiation of dietary administration, mice were infected intranasally with influenza virus A/PR/8/34 (H1N1). Survival rate was monitored 10 days after infection. In adition, we performed virus titer and cytokine profiles in the lung. High survival rates were observed for Euglena gracilis Z and paramylon-treated groups compared to the control group. Significantly lower virus titer in the lung was observed in the Euglena gracilis Z and paramylon-treated groups compared to the control group from day 1 after infection. Higher amount of IL-1β, IL-6, IL-12 (p70), IFN-γ, and IL-10 was observed in the paramylon groups compared to the control group. Our data therefore reveals a novel immunoregulatory role of the Euglena gracilis Z and paramylon which provides protection against influenza virus infection.
Copyright ? 2017. Published by Elsevier Inc.
KEYWORDS:
Euglena gracilis Z; Influenza virus; Interferon-γ; Interleukin-12; Paramylon; β-1, 3-D-glucan
PMID: 28974421 DOI: 10.1016/j.bbrc.2017.09.167
Oral administration of Euglena gracilis Z and its carbohydrate storage substance provides survival protection against influenza virus infection in mice.
Nakashima A1, Suzuki K1, Asayama Y1, Konno M2, Saito K2, Yamazaki N2, Takimoto H3.
Author information
Abstract
Euglena gracilis Z is a micro-algae that is used as a food or nutritional supplement. Paramylon, the carbohydrate storage substance of Euglena gracilis Z has β-1, 3-glucan structure. Euglena gracilis Z and paramylon are reported to affect the immune system. In this study, we investigated the protective effects of Euglena gracilis Z and paramylon against influenza virus infection in mice. Euglena gracilis Z and paramylon were administered to mice as a 2% dietary mixture ad libitum. At 2 weeks after initiation of dietary administration, mice were infected intranasally with influenza virus A/PR/8/34 (H1N1). Survival rate was monitored 10 days after infection. In adition, we performed virus titer and cytokine profiles in the lung. High survival rates were observed for Euglena gracilis Z and paramylon-treated groups compared to the control group. Significantly lower virus titer in the lung was observed in the Euglena gracilis Z and paramylon-treated groups compared to the control group from day 1 after infection. Higher amount of IL-1β, IL-6, IL-12 (p70), IFN-γ, and IL-10 was observed in the paramylon groups compared to the control group. Our data therefore reveals a novel immunoregulatory role of the Euglena gracilis Z and paramylon which provides protection against influenza virus infection.
Copyright ? 2017. Published by Elsevier Inc.
KEYWORDS:
Euglena gracilis Z; Influenza virus; Interferon-γ; Interleukin-12; Paramylon; β-1, 3-D-glucan
PMID: 28974421 DOI: 10.1016/j.bbrc.2017.09.167