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In vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21

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  • In vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21

    Biocontrol Sci. 2017;22(3):171-174. doi: 10.4265/bio.22.171.
    In vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21.

    Eguchi N1,2, Fujino K1,2, Thanasut K1, Taharaguchi M3, Motoi M4, Motoi A4, Oonaka K5, Taharaguchi S1.
    Author information

    Abstract

     Agaricus is known to have immunostimulatory and anti-tumor effects. However, the antiviral effects of Agaricus have not yet been examined. In the present study, the antiviral effects of an extract of Agaricus brasiliensis KA21 (AE) on the H1N1 influenza virus (PR8 strain) were investigated. The anti-influenza virus effects of AE were examined by using the plaque formation inhibition test. AE inhibited the plaque formation of PR8 in a dose-dependent manner: 98 and 50% (IC50) inhibition at 2.5 and 0.99 mg/mL, respectively. To elucidate the mechanisms of AE, the direct actions and adsorption and invasion inhibition of AE were examined, and were found to have no inhibitory effect on PR8 infection. Thus, in vitro antiviral effects may somehow inhibit PR8 after the viral invasion of cells. These results demonstrated that it is expected that AE can effectively prevent the spread of the influenza virus.


    KEYWORDS:

    Agaricus brasiliensis; Anti-influenza virus

    PMID: 28954960 DOI: 10.4265/bio.22.171
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