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Biomed Chromatogr. 2017 Sep 15. doi: 10.1002/bmc.4097. [Epub ahead of print]
Material Basis Studies of Anti-Influenza A Active Ingredients in Tanreqing Injection.
Zhu H1, Chen M2, Shi X1, Shi C1, Huang C2.
Author information
Abstract
Tanreqing Injection (TRQ) has been used primarily in treating infections of the upper respiratory tract and serious influenza in China, as a classical compound herbal recipe. TRQ had been demonstrated its effects of clearing heat, eliminating phlegm, detoxification, reducing inflammation and alleviating cough. The survival rate, histopathology of lungs and viral titers in mice were evaluated in this study to verify the curative effect of TRQ. However, there is not enough information about the components. In the present study, a high-performance and practical LC/QTOF/MS method was developed for characterization and identification of the natural ingredients in TRQ. A total of 60 compounds, including 10 amino acids, 10 iridoid glucosides, 14 flavonoids, 13 other phenolic compounds, 10 steroid acids and 3 other compounds were characterized and identified. And we confirmed the material basis of Anti-influenza A active ingredients in TRQ. Therefore, we have developed an accurate analytical method. LC/QTOF/MS could be applied for identification the complex components in Traditional Chinese Medicine.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Antiviral research; Component analysis; Influenza A Virus; LC/QTOF/MS; Tanreqing Injection
PMID: 28921579 DOI: 10.1002/bmc.4097
Material Basis Studies of Anti-Influenza A Active Ingredients in Tanreqing Injection.
Zhu H1, Chen M2, Shi X1, Shi C1, Huang C2.
Author information
Abstract
Tanreqing Injection (TRQ) has been used primarily in treating infections of the upper respiratory tract and serious influenza in China, as a classical compound herbal recipe. TRQ had been demonstrated its effects of clearing heat, eliminating phlegm, detoxification, reducing inflammation and alleviating cough. The survival rate, histopathology of lungs and viral titers in mice were evaluated in this study to verify the curative effect of TRQ. However, there is not enough information about the components. In the present study, a high-performance and practical LC/QTOF/MS method was developed for characterization and identification of the natural ingredients in TRQ. A total of 60 compounds, including 10 amino acids, 10 iridoid glucosides, 14 flavonoids, 13 other phenolic compounds, 10 steroid acids and 3 other compounds were characterized and identified. And we confirmed the material basis of Anti-influenza A active ingredients in TRQ. Therefore, we have developed an accurate analytical method. LC/QTOF/MS could be applied for identification the complex components in Traditional Chinese Medicine.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Antiviral research; Component analysis; Influenza A Virus; LC/QTOF/MS; Tanreqing Injection
PMID: 28921579 DOI: 10.1002/bmc.4097