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Tackling influenza with broadly neutralizing antibodies

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  • Tackling influenza with broadly neutralizing antibodies

    Curr Opin Virol. 2017 May 18;24:60-69. doi: 10.1016/j.coviro.2017.03.002. [Epub ahead of print]
    Tackling influenza with broadly neutralizing antibodies.

    Corti D1, Cameroni E2, Guarino B2, Kallewaard NL3, Zhu Q3, Lanzavecchia A4.
    Author information

    Abstract

    Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity and inflammatory conditions and represent a new frontier for the treatment of infectious diseases. In the last decade, new methods have allowed the efficient interrogation of the human antibody repertoire from influenza immune individuals and the isolation of several monoclonal antibodies capable of dealing with the high variability of influenza viruses. Here, we will provide a comprehensive overview of the specificity, antiviral and immunological mechanisms of action and development into the clinic of broadly reactive monoclonal antibodies against influenza A and B viruses.
    Copyright ? 2017 Elsevier B.V. All rights reserved.


    PMID: 28527859 DOI: 10.1016/j.coviro.2017.03.002
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