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EBioMedicine. 2017 Apr 6. pii: S2352-3964(17)30153-6. doi: 10.1016/j.ebiom.2017.04.010. [Epub ahead of print]
Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection.
Rockman S1, Lowther S2, Camuglia S3, Vandenberg K3, Taylor S4, Fabri L4, Miescher S5, Pearse M4, Middleton D2, Kent SJ6, Maher D7.
Author information
Abstract
Influenza is a highly contagious, acute, febrile respiratory infection that can have fatal consequences particularly in individuals with chronic illnesses. Sporadic reports suggest that intravenous immunoglobulin (IVIg) may be efficacious in the influenza setting. We investigated the potential of human IVIg to ameliorate influenza infection in ferrets exposed to either the pandemic H1N1/09 virus (pH1N1) or highly pathogenic avian influenza (H5N1). IVIg administered at the time of influenza virus exposure led to a significant reduction in lung viral load following pH1N1 challenge. In the lethal H5N1 model, the majority of animals given IVIg survived challenge in a dose dependent manner. Protection was also afforded by purified F(ab')2 but not Fc fragments derived from IVIg, supporting a specific antibody-mediated mechanism of protection. We conclude that pre-pandemic IVIg can modulate serious influenza infection-associated mortality and morbidity. IVIg could be useful prophylactically in the event of a pandemic to protect vulnerable population groups and in the critical care setting as a first stage intervention.
Copyright ? 2017. Published by Elsevier B.V.
KEYWORDS:
Antibody; IVIg; Influenza; Intravenous immunoglobulin; Passive immunotherapy; Plasma; Serum
PMID: 28408242 DOI: 10.1016/j.ebiom.2017.04.010
Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection.
Rockman S1, Lowther S2, Camuglia S3, Vandenberg K3, Taylor S4, Fabri L4, Miescher S5, Pearse M4, Middleton D2, Kent SJ6, Maher D7.
Author information
Abstract
Influenza is a highly contagious, acute, febrile respiratory infection that can have fatal consequences particularly in individuals with chronic illnesses. Sporadic reports suggest that intravenous immunoglobulin (IVIg) may be efficacious in the influenza setting. We investigated the potential of human IVIg to ameliorate influenza infection in ferrets exposed to either the pandemic H1N1/09 virus (pH1N1) or highly pathogenic avian influenza (H5N1). IVIg administered at the time of influenza virus exposure led to a significant reduction in lung viral load following pH1N1 challenge. In the lethal H5N1 model, the majority of animals given IVIg survived challenge in a dose dependent manner. Protection was also afforded by purified F(ab')2 but not Fc fragments derived from IVIg, supporting a specific antibody-mediated mechanism of protection. We conclude that pre-pandemic IVIg can modulate serious influenza infection-associated mortality and morbidity. IVIg could be useful prophylactically in the event of a pandemic to protect vulnerable population groups and in the critical care setting as a first stage intervention.
Copyright ? 2017. Published by Elsevier B.V.
KEYWORDS:
Antibody; IVIg; Influenza; Intravenous immunoglobulin; Passive immunotherapy; Plasma; Serum
PMID: 28408242 DOI: 10.1016/j.ebiom.2017.04.010