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Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

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  • Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

    Biologics. 2017 Mar 10;11:23-30. doi: 10.2147/BTT.S123831. eCollection 2017.
    Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin.

    Onodera H1, Urayama T2, Hirota K3, Maeda K3, Kubota-Koketsu R4, Takahashi K5, Hagiwara K6, Okuno Y3, Ikuta K4, Yunoki M7.
    Author information

    Abstract

    Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured by standard methods. The VN titer was measured using a micro-focus method. IVIG exhibited significant HI and VN titers against all investigated strains. Our results suggest that the donor population maintains both specific and cross-reactive antibodies against seasonal influenza viruses, except in cases of pandemic viruses, despite major antigen changes. The titers against seasonal influenza vaccine strains, including past strains, were stable over short time periods but increased slowly over time.


    KEYWORDS:

    IVIG; influenza; neutralization; seasonal; vaccine

    PMID: 28331286 PMCID: PMC5354529 DOI: 10.2147/BTT.S123831
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