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New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention

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  • New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention

    Phytomedicine. 2017 Apr 15;27:52-62. doi: 10.1016/j.phymed.2017.02.004. Epub 2017 Feb 14.
    New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention.

    Chen H1, Jie C1, Tang LP1, Meng H2, Li XB1, Li YB1, Chen LX1, Yan C1, Kurihara H3, Li YF4, He RR5.
    Author information

    Abstract

    BACKGROUND:

    KangBingDu (KBD) is a classic traditional Chinese medicinal formula widely used to treat influenza. However, little information is available from controlled studies regarding the anti-influenza pharmacological activities of KBD and its underlying mechanisms, at least partly due to the lack of appropriate study models.
    PURPOSE:

    We hypothesized that KBD might provide a protection against influenza infection by reducing the host's susceptibility to viruses. To prove it, mouse restraint stress model was employed.
    METHODS:

    Mice were restricted and infected with influenza virus. KBD (13 and 26mg/kg/d) was orally administrated to mice from the first day of restraint stress and lasted for 7 days (twice a day). Mice were monitored daily for morbidity, symptom severity, and mortality for 21 days. The histopathologic changes were examined. For the study of mechanisms of action, we investigated whether KBD could promote mitochondria antiviral signaling protein (MAVS)-mediated antiviral signal and inhibit nuclear factor-kappa B (NF-κB)-mediated inflammation response.
    RESULTS:

    KBD significantly decreased the susceptibility of restraint mice to influenza virus, as evidenced by lowered mortality, attenuated inflammation and reduced viral replications in lungs. Further results revealed that KBD elevated the protein expression of MAVS, which subsequently increased the IFN-β and IFITM3 protein levels, thereby helping to fight viral infections. Finally, we identified that (R,S)-goitrin, mangiferin, forsythin and forsythoside A were effective components in KBD against influenza viral infections.
    CONCLUSION:

    KBD can reduce the susceptibility to influenza virus via mitochondrial antiviral signaling.
    Copyright ? 2017 Elsevier GmbH. All rights reserved.


    KEYWORDS:

    Influenza virus; KangBingDu (KBD); Restraint stress; Susceptibility; Traditional Chinese medicine

    PMID: 28314479 DOI: 10.1016/j.phymed.2017.02.004
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