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Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

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  • Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

    Viruses. 2016 Sep 29;8(10). pii: E269.
    Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.

    S?derholm S1,2, Fu Y3, Gaelings L4, Belanov S5, Yetukuri L6, Berlinkov M7, Cheltsov AV8, Anders S9, Aittokallio T10,11, Nyman TA12, Matikainen S13,14, Kainov DE15.
    Author information

    Abstract

    Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.


    KEYWORDS:

    antiviral agent; genomics; influenza virus; metabolomics; phosphoproteomics; proteomics; transcriptomics; virtual ligand screening

    PMID: 27690086 DOI: 10.3390/v8100269
    [PubMed - as supplied by publisher] Free full text
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