Announcement

Collapse
No announcement yet.

The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy

    Pharmaceuticals (Basel). 2016 Sep 6;9(3). pii: E53. doi: 10.3390/ph9030053.
    The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy.

    Hsieh IN1, Hartshorn KL2.
    Author information

    Abstract

    Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been emerging, and antimicrobial peptides (AMPs) have been considered to be potential candidates for novel treatment against IAV infection. AMPs are endogenous proteins playing important roles in host defense through direct antimicrobial and antiviral activities and through immunomodulatory effects. In this review, we will discuss the anti-IAV and immunomodulatory effects of classical AMPs (defensins and cathelicidins), and proteins more recently discovered to have AMP-like activity (histones and Alzheimer's associated β-amyloid). We will discuss the interactions between AMPs and other host defense proteins. Major emphasis will be placed on novel synthetic AMPs derived from modification of natural proteins, and on potential methods of increasing expression of endogenous AMPs, since these approaches may lead to novel antiviral therapeutics.


    KEYWORDS:

    LL-37; amyloid; cathelicidin; defensin; histone

    PMID: 27608030 DOI: 10.3390/ph9030053
    [PubMed] Free full text
Working...
X