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Influenza Other Respir Viruses. 2016 Aug 20. doi: 10.1111/irv.12421. [Epub ahead of print]
Antiviral activity of aspirin against RNA viruses of the respiratory tract - an in vitro study.
Glatthaar-Saalm?ller B1,2, Mair KH2, Saalm?ller A2.
Author information
Abstract
AIM:
Aspirin (Acetylsalicylic acid) has been used for more than 115 years in medicine. Research exists to show that aspirin has antiviral effects in vitro e.g. by blocking influenza virus propagation via NF-κB inhibition when used at high concentrations and short-term incubation steps. The aim of this study was to confirm the antiviral activity of aspirin against influenza virus and further elucidate the activity of aspirin against other respiratory viruses.
METHODS:
Tests to detect antiviral activity were performed using plaque-reduction assays. Aspirin was administered to the virus-infected cell cultures one hour after infection. Prior to these assays, the non-cytotoxic concentrations of aspirin on cells used for propagation of the respective viruses were determined.
RESULTS:
Aspirin was found to be highly effective against influenza A H1N1 virus. The antiviral activity against further respiratory RNA viruses was less distinct. Respiratory syncytial virus was minimally inhibited. However, the activity of aspirin against rhinoviruses was more pronounced. Aspirin demonstrated antiviral activity against all human rhinoviruses (HRV) but the effect on members of the "major group" viruses, namely HRV14 and HRV39, was greater than on those of the "minor group", HRV1A and HRV2.
CONCLUSIONS:
These data demonstrate a specific antiviral activity of aspirin against influenza A virus and HRV. The mode of action against rhinoviruses is still unknown and requires further investigation, as does the possibility of aspirin being effective in vivo to treat the common cold. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
acetylsalicylic acid; antiviral activity; aspirin; influenza; plaque reduction assay; rhinoviruses
PMID: 27542891 DOI: 10.1111/irv.12421
[PubMed - as supplied by publisher] Free full text
Antiviral activity of aspirin against RNA viruses of the respiratory tract - an in vitro study.
Glatthaar-Saalm?ller B1,2, Mair KH2, Saalm?ller A2.
Author information
Abstract
AIM:
Aspirin (Acetylsalicylic acid) has been used for more than 115 years in medicine. Research exists to show that aspirin has antiviral effects in vitro e.g. by blocking influenza virus propagation via NF-κB inhibition when used at high concentrations and short-term incubation steps. The aim of this study was to confirm the antiviral activity of aspirin against influenza virus and further elucidate the activity of aspirin against other respiratory viruses.
METHODS:
Tests to detect antiviral activity were performed using plaque-reduction assays. Aspirin was administered to the virus-infected cell cultures one hour after infection. Prior to these assays, the non-cytotoxic concentrations of aspirin on cells used for propagation of the respective viruses were determined.
RESULTS:
Aspirin was found to be highly effective against influenza A H1N1 virus. The antiviral activity against further respiratory RNA viruses was less distinct. Respiratory syncytial virus was minimally inhibited. However, the activity of aspirin against rhinoviruses was more pronounced. Aspirin demonstrated antiviral activity against all human rhinoviruses (HRV) but the effect on members of the "major group" viruses, namely HRV14 and HRV39, was greater than on those of the "minor group", HRV1A and HRV2.
CONCLUSIONS:
These data demonstrate a specific antiviral activity of aspirin against influenza A virus and HRV. The mode of action against rhinoviruses is still unknown and requires further investigation, as does the possibility of aspirin being effective in vivo to treat the common cold. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
acetylsalicylic acid; antiviral activity; aspirin; influenza; plaque reduction assay; rhinoviruses
PMID: 27542891 DOI: 10.1111/irv.12421
[PubMed - as supplied by publisher] Free full text