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Eur J Med Chem. 2016 Jul 25;123:236-255. doi: 10.1016/j.ejmech.2016.07.056. [Epub ahead of print]
Therapeutic potential of coumarins as antiviral agents.
Hassan MZ1, Osman H2, Ali MA3, Ahsan MJ4.
Author information
Abstract
Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.
Copyright ? 2016 Elsevier Masson SAS. All rights reserved.
KEYWORDS:
Anti-HCV; Anti-HIV; Anti-herpes; Anti-influenza; Antiviral; Coumarin
PMID: 27484512 DOI: 10.1016/j.ejmech.2016.07.056
[PubMed - as supplied by publisher]
Therapeutic potential of coumarins as antiviral agents.
Hassan MZ1, Osman H2, Ali MA3, Ahsan MJ4.
Author information
Abstract
Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.
Copyright ? 2016 Elsevier Masson SAS. All rights reserved.
KEYWORDS:
Anti-HCV; Anti-HIV; Anti-herpes; Anti-influenza; Antiviral; Coumarin
PMID: 27484512 DOI: 10.1016/j.ejmech.2016.07.056
[PubMed - as supplied by publisher]