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Arch Pharm Res. 2016 Jun 21. [Epub ahead of print]
Protective effects of phillyrin against influenza A virus in vivo.
Qu XY1, Li QJ1, Zhang HM2, Zhang XJ1, Shi PH1, Zhang XJ1, Yang J3, Zhou Z4, Wang SQ5.
Author information
Abstract
Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.
KEYWORDS:
Influenza A virus; Mouse; Phillyrin
PMID: 27323762 [PubMed - as supplied by publisher]
Protective effects of phillyrin against influenza A virus in vivo.
Qu XY1, Li QJ1, Zhang HM2, Zhang XJ1, Shi PH1, Zhang XJ1, Yang J3, Zhou Z4, Wang SQ5.
Author information
Abstract
Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.
KEYWORDS:
Influenza A virus; Mouse; Phillyrin
PMID: 27323762 [PubMed - as supplied by publisher]