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Arch Virol. 2009 Sep 23. [Epub ahead of print]
Anti-influenza-virus activity of total alkaloids from Commelina communis L.
Bing FH, Liu J, Li Z, Zhang GB, Liao YF, Li J, Dong CY. - Key Laboratory of TCM Resource and Compound Prescription, Ministry of Education, Hubei College of Traditional Chinese Medicine, 430065, Wuhan, China, bingfeihong@126.com.
The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.
PMID: 19774337 [PubMed - as supplied by publisher]
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Anti-influenza-virus activity of total alkaloids from Commelina communis L.
Bing FH, Liu J, Li Z, Zhang GB, Liao YF, Li J, Dong CY. - Key Laboratory of TCM Resource and Compound Prescription, Ministry of Education, Hubei College of Traditional Chinese Medicine, 430065, Wuhan, China, bingfeihong@126.com.
The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.
PMID: 19774337 [PubMed - as supplied by publisher]
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