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  • ASA inhibits viral reproduction

    Cellular Microbiology



    To cite this article: Igor Mazur, Walter J. Wurzer, Christina Ehrhardt, Stephan Pleschka, Pilaipan Puthavathana, Tobias Silberzahn, Thorsten Wolff, Oliver Planz, Stephan Ludwig

    Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-κB-inhibiting activity

    Cellular Microbiology (OnlineEarly Articles).
    doi:10.1111/j.1462-5822.2007.00902.x

    Accepted article online:
    30 Jan 2007
    Published article online:
    23 Feb 2007


    Original Article
    Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-κB-inhibiting activity

    * Igor Mazur,11Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von-Esmarch-Street 56, D-48149 Muenster, Germany.
    * Walter J. Wurzer,1+1Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von-Esmarch-Street 56, D-48149 Muenster, Germany.+Present address: Aventis Pharma, Saturn Tower, Leonard-Bernstein Strasse 10, A-1220 Vienna, Austria.
    * Christina Ehrhardt,11Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von-Esmarch-Street 56, D-48149 Muenster, Germany.
    * Stephan Pleschka,22Institute of Medical Virology, Justus-Liebig-University, Frankfurter Strasse 107, D-35392 Giessen, Germany.
    * Pilaipan Puthavathana,33Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
    * Tobias Silberzahn,44Friedrich-Loeffler-Institute (FLI), Paul-Ehrlich-Strasse 28, D-72076 T?bingen, Germany.
    * Thorsten Wolff,55Robert-Koch-Institute (RKI), Nordufer 20, D-13353 Berlin, Germany.
    * Oliver Planz44Friedrich-Loeffler-Institute (FLI), Paul-Ehrlich-Strasse 28, D-72076 T?bingen, Germany.**E-mail ludwigs@uni-muenster.de; Tel. (+49) 251 83 57791; Fax (+49) 251 83 57793; E-mail oliver.planz@fli.bund.de; Tel. (+49) 7071 967 254; Fax (+49) 7071 967 105.These two authors have equally contributed to the study. and
    * Stephan Ludwig11Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von-Esmarch-Street 56, D-48149 Muenster, Germany.**E-mail ludwigs@uni-muenster.de; Tel. (+49) 251 83 57791; Fax (+49) 251 83 57793; E-mail oliver.planz@fli.bund.de; Tel. (+49) 7071 967 254; Fax (+49) 7071 967 105.These two authors have equally contributed to the study.

    *
    1Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von-Esmarch-Street 56, D-48149 Muenster, Germany.
    2Institute of Medical Virology, Justus-Liebig-University, Frankfurter Strasse 107, D-35392 Giessen, Germany.
    3Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
    4Friedrich-Loeffler-Institute (FLI), Paul-Ehrlich-Strasse 28, D-72076 T?bingen, Germany.
    5Robert-Koch-Institute (RKI), Nordufer 20, D-13353 Berlin, Germany.

    *E-mail ludwigs@uni-muenster.de; Tel. (+49) 251 83 57791; Fax (+49) 251 83 57793; E-mail oliver.planz@fli.bund.de; Tel. (+49) 7071 967 254; Fax (+49) 7071 967 105.
    Summary


    Influenza is still one of the major plagues worldwide. The statistical likeliness of a new pandemic outbreak highlights the urgent need for new and amply available antiviral drugs. We and others have shown that influenza virus misuses the cellular IKK/NF-κB signalling pathway for efficient replication suggesting that this module may be a suitable target for antiviral intervention. Here we examined acetylsalicylic acid (ASA), also known as aspirin, a widely used drug with a well-known capacity to inhibit NF-κB. We show that the drug efficiently blocks influenza virus replication in vitro and in vivo in a mechanism involving impaired expression of proapoptotic factors, subsequent inhibition of caspase activation as well as block of caspase-mediated nuclear export of viral ribonucleoproteins. As ASA showed no toxic side-effects or the tendency to induce resistant virus variants, existing salicylate-based aerosolic drugs may be suitable as anti-influenza agents. This is the first demonstration that specific targeting of a cellular factor is a suitable approach for anti-influenza virus intervention.

  • #2
    Re: ASA inhibits viral reproduction

    Thank you G?nseerpel,

    I am surprise of the conclusions, I will try to find it, but few years ago we took knowledge of the problems of ASA and its effects on cytokines.

    I will try to find it out.

    Comment


    • #3
      Re: ASA inhibits viral reproduction

      I was wondering if there was a link to this article? Got it. http://www.blackwell-synergy.com/doi...2.2007.00902.x

      Comment

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