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Chest. Repair of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Endothelial Progenitor Cells, Alone and in Combination With Simvastatin

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  • Chest. Repair of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Endothelial Progenitor Cells, Alone and in Combination With Simvastatin

    [Source: Chest, full page: (LINK). Abstract, edited.]


    Original Research | September 2013

    Repair of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Endothelial Progenitor Cells, Alone and in Combination With Simvastatin

    Hao Li, MD; Yong Qiang, MMed; Lian Wang, MD; Gaoming Wang, MMed; Jun Yi, MD; Hua Jing, MMed; Haiwei Wu, MD

    Author and Funding Information: From the Department of Cardiothoracic Surgery (Drs Li, Qiang, L. Wang, Yi, and Wu and Prof Jing), Jinling Hospital, Clinical Medicine School of Nanjing University, Nanjing; and the Department of Cardiothoracic Surgery (Dr G. Wang), Xuzhou Central Hospital, Xuzhou, China.

    Correspondence to: Haiwei Wu, MD, 305 Zhongshan E Rd, Nanjing, China; e-mail: wuhaiweicts@163.com

    Funding/Support: This study was supported by research grant from the Natural Science Foundation of China [30972969].

    Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.

    Chest. 2013;144(3):876-886. doi:10.1378/chest.12-2429. Published online.


    Abstract

    Background:

    Endothelial progenitor cells (EPCs) are involved in endothelium repair of acute lung injury (ALI). Numerous studies have demonstrated that statins can promote EPC function in vitro and in vivo; therefore, the purpose of this study was to determine whether simvastatin enhances the function of EPCs participating in the repair of ALI.


    Methods:

    BALB/C mice were initially pretreated with simvastatin by intraperitoneal administration 24 h before, and again at the time of, intratracheal instillation of lipopolysaccharide (LPS) and subsequently treated with EPCs by IV transplantation 2 h later. The effects of capillary permeability, endothelium repair, and inflammatory cytokines were measured.


    Results:

    This study revealed that both simvastatin administration and EPC transplantation can reduce the severity of LPS-induced ALI in mice, and the effect can be further improved by combining the two therapies.


    Conclusions:

    The administration of simvastatin and EPC transplantation can reduce the severity of LPS-induced ALI in mice, and improvement is moderately enhanced in some respects when EPC transplantation is combined with simvastatin administration. The beneficial role of simvastatin on EPCs may be a component of its pleiotropic effects. Although the exact mechanism remains unknown, the combined administration of simvastatin and EPC transplantation may be a potentially important, cell-based, inflammation-mediated therapy for patients with ALI/ARDS.


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