Announcement

Collapse
No announcement yet.

Front Cell Infect Microbiol . Phylogenetic and mutational analysis of H10N3 avian influenza A virus in China: potential threats to human health

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Front Cell Infect Microbiol . Phylogenetic and mutational analysis of H10N3 avian influenza A virus in China: potential threats to human health

    Front Cell Infect Microbiol


    . 2024 Jun 24:14:1433661.
    doi: 10.3389/fcimb.2024.1433661. eCollection 2024. Phylogenetic and mutational analysis of H10N3 avian influenza A virus in China: potential threats to human health

    Jingyi Dai # 1 , Jun Zhao # 2 , Jiawei Xia # 1 , Pei Zhang 1 , Yadi Ding 1 , Qiujing Li 1 , Min Hou 3 , Xianhui Xiong 3 , Qianqi Jian 3 , Yanyan Liu 3 , Guiming Liu 1



    AffiliationsAbstract

    In recent years, the avian influenza virus has emerged as a significant threat to both human and public health. This study focuses on a patient infected with the H10N3 subtype of avian influenza virus, admitted to the Third People's Hospital of Kunming City on March 6, 2024. Metagenomic RNA sequencing and polymerase chain reaction (PCR) analysis were conducted on the patient's sputum, confirming the H10N3 infection. The patient presented severe pneumonia symptoms such as fever, expectoration, chest tightness, shortness of breath, and cough. Phylogenetic analysis of the Haemagglutinin (HA) and neuraminidase (NA) genes of the virus showed that the virus was most closely related to a case of human infection with the H10N3 subtype of avian influenza virus found in Zhejiang Province, China. Analysis of amino acid mutation sites identified four mutations potentially hazardous to human health. Consequently, this underscores the importance of continuous and vigilant monitoring of the dynamics surrounding the H10N3 subtype of avian influenza virus, utilizing advanced genomic surveillance techniques.

    Keywords: H10N3; avian influenza A virus; human infection; mutation; phylogeny analysis.

    ‚Äč
Working...
X