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Prevalence of antibodies against seasonal influenza a and b viruses in children in the netherlands

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  • Prevalence of antibodies against seasonal influenza a and b viruses in children in the netherlands

    Clin Vaccine Immunol. 2011 Jan 5. [Epub ahead of print]
    PREVALENCE OF ANTIBODIES AGAINST SEASONAL INFLUENZA A AND B VIRUSES IN CHILDREN IN THE NETHERLANDS.

    Bodewes R, de Mutsert G, van der Klis FR, Ventresca M, Wilks S, Smith DJ, Koopmans M, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.

    Department of Virology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands; National Institute for Public Health and the Environment, Laboratory for Infectious Diseases and Screening, PO Box 1, 3720 BA Bilthoven, The Netherlands; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom; Viroclinics Biosciences BV, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
    Abstract

    To gain insight in the age at which children become infected with influenza viruses for the first time, we analyzed the seroprevalence of antibodies against influenza viruses in children 0-7 years of age in The Netherlands. Serum samples were collected during a cross-sectional population-based study in 2006 and 2007 and were tested for the presence of antibodies against influenza A/H1N1, A/H3N2 and B viruses representative for previous influenza seasons using the hemagglutination inhibition assay. The seroprevalence of antibodies to influenza was higher in children 1-6 months of age than that of children 7-12 months of age, which likely reflects the presence of maternally derived antibodies. The proportion of study subjects >1 year of age with detectable antibodies against influenza viruses gradually increased with age until they reached the age of six when they all had antibodies to at least one influenza A virus. These findings may have implications for the development of vaccination strategies aiming at the protection of young children against seasonal and/or pandemic influenza virus infection.

    PMID: 21209157 [PubMed - as supplied by publisher]

    To gain insight into the age at which children become infected with influenza viruses for the first time, we analyzed the seroprevalence of antibodies against influenza viruses in children 0 to 7 years of age in the Netherlands. Serum samples were collected during a cross-sectional population-based …
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