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J Infect Dis
. 2024 Feb 8:jiae070.
doi: 10.1093/infdis/jiae070. Online ahead of print. Risk of cardiovascular events after influenza: A population-based Self Controlled Case Series study, Spain 2011-2018
Cintia Muñoz-Quiles 1 2 , Mónica López-Lacort 1 2 , Arantxa Urchueguía 1 2 , Javier Díez-Domingo 1 2 3 , Alejandro Orrico-Sánchez 1 2 3
Affiliations
This study explores the relationship between influenza infection, both clinically diagnosed in primary-care and laboratory confirmed in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self-controlled case series design was used with individual-level data from electronic registries (n = 2,230,015). The risk of atherothrombotic events in subjects ≥50 years old increased more than 2-fold during the 14 days after the mildest influenza cases in patients with fewer risk factors and more than 4-fold after severe cases in the most vulnerable patients, remaining in them more than 2-fold for 2 months. The transient increase of the association, its gradient after influenza infection and the demonstration by 4 different sensitivity analyses provide further evidence supporting causality. This work reinforces the official recommendations for influenza prevention in at-risk groups and should also increase the awareness of even milder influenza infection and its possible complications in the general population.
Keywords: Influenza; atherothrombotic; cardiovascular; clinically diagnosed influenza; electronic healthcare registries; ischemic stroke; laboratory confirmed influenza; myocardial infarction; population-based; self-controlled case-series.
. 2024 Feb 8:jiae070.
doi: 10.1093/infdis/jiae070. Online ahead of print. Risk of cardiovascular events after influenza: A population-based Self Controlled Case Series study, Spain 2011-2018
Cintia Muñoz-Quiles 1 2 , Mónica López-Lacort 1 2 , Arantxa Urchueguía 1 2 , Javier Díez-Domingo 1 2 3 , Alejandro Orrico-Sánchez 1 2 3
Affiliations
- PMID: 38330324
- DOI: 10.1093/infdis/jiae070
This study explores the relationship between influenza infection, both clinically diagnosed in primary-care and laboratory confirmed in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self-controlled case series design was used with individual-level data from electronic registries (n = 2,230,015). The risk of atherothrombotic events in subjects ≥50 years old increased more than 2-fold during the 14 days after the mildest influenza cases in patients with fewer risk factors and more than 4-fold after severe cases in the most vulnerable patients, remaining in them more than 2-fold for 2 months. The transient increase of the association, its gradient after influenza infection and the demonstration by 4 different sensitivity analyses provide further evidence supporting causality. This work reinforces the official recommendations for influenza prevention in at-risk groups and should also increase the awareness of even milder influenza infection and its possible complications in the general population.
Keywords: Influenza; atherothrombotic; cardiovascular; clinically diagnosed influenza; electronic healthcare registries; ischemic stroke; laboratory confirmed influenza; myocardial infarction; population-based; self-controlled case-series.