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Math Biosci Eng . Improved uniform persistence for partially diffusive models of infectious diseases: cases of avian influenza and Ebola virus disease

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  • Math Biosci Eng . Improved uniform persistence for partially diffusive models of infectious diseases: cases of avian influenza and Ebola virus disease

    Math Biosci Eng


    . 2023 Oct 26;20(11):19686-19709.
    doi: 10.3934/mbe.2023872. Improved uniform persistence for partially diffusive models of infectious diseases: cases of avian influenza and Ebola virus disease

    Ryan Covington 1 , Samuel Patton 1 , Elliott Walker 1 , Kazuo Yamazaki 2



    AffiliationsAbstract

    Past works on partially diffusive models of diseases typically rely on a strong assumption regarding the initial data of their infection-related compartments in order to demonstrate uniform persistence in the case that the basic reproduction number $ \mathcal{R}_0 $ is above 1. Such a model for avian influenza was proposed, and its uniform persistence was proven for the case $ \mathcal{R}_0 > 1 $ when all of the infected bird population, recovered bird population and virus concentration in water do not initially vanish. Similarly, a work regarding a model of the Ebola virus disease required that the infected human population does not initially vanish to show an analogous result. We introduce a modification on the standard method of proving uniform persistence, extending both of these results by weakening their respective assumptions to requiring that only one (rather than all) infection-related compartment is initially non-vanishing. That is, we show that, given $ \mathcal{R}_0 > 1 $, if either the infected bird population or the viral concentration are initially nonzero anywhere in the case of avian influenza, or if any of the infected human population, viral concentration or population of deceased individuals who are under care are initially nonzero anywhere in the case of the Ebola virus disease, then their respective models predict uniform persistence. The difficulty which we overcome here is the lack of diffusion, and hence the inability to apply the minimum principle, in the equations of the avian influenza virus concentration in water and of the population of the individuals deceased due to the Ebola virus disease who are still in the process of caring.

    Keywords: Ebola virus disease; avian influenza; basic reproduction number; global attractivity; spatial diffusion; uniform persistence.

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