J Infect . H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profiles

[tetano]

J Infect


. 2022 Oct 20;S0163-4453(22)00622-3.
doi: 10.1016/j.jinf.2022.10.023. Online ahead of print.
H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profiles


Jingman Tian ¹ , Minghui Li ¹ , Yulei Li ¹ , Xiaoli Bai ¹ , Xingdong Song ¹ , Zhiguo Zhao ¹ , Shenfeng Ge ² , Yuehui Li ² , Jianwen Liu ² , Jianzhong Shi ¹ , Xiaoliang Wang ³ , Zhixin Li ³ , Haining Zhou ³ , Long Ma ³ , Xianying Zeng ¹ , Guobin Tian ¹ , Yuntao Guan ¹ , Yanbing Li ⁴ , Hualan Chen ⁵



Affiliations

• PMID: 36273641
• DOI: 10.1016/j.jinf.2022.10.023

Abstract

We present the phylogeny, receptor binding property, growth in mammal cells and pathogenicity in mammal model of H3N8 viruses, which were isolated from wild birds in China. The human receptor preference and efficient replication in mice without prior adaption highlight that the H3N8 virus possesses the public threat potential.

Keywords: China; H3N8; Phylogeny; Receptor binding; Virulence; Wild birds.