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Emerg Infect Dis. Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Influenza A (H7N7) Epidemic, the Netherlands, 2003
PPE and Oseltamivir Use (Emerg Infect Dis., abstract, edited)
[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Journal, full text: <cite cite="http://www.cdc.gov/eid/content/16/10/1562.htm">PPE and Oseltamivir Use | CDC EID</cite>. Abstract, edited.]
Volume 16, Number 10?October 2010
Research
Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Influenza A (H7N7) Epidemic, the Netherlands, 2003
Dennis E. te Beest
Comments to Author, Michiel van Boven, Marian E.H. Bos, Arjan Stegeman, and Marion P.G. Koopmans
Author affiliations: Utrecht University, Utrecht, the Netherlands (D.E. te Beest, M.E.H. Bos, A. Stegeman); and National Institute of Public Health and the Environment, Bilthoven, the Netherlands (D.E. te Beest, M. van Boven, M.P.G. Koopmans)
Abstract
We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95% confidence interval [CI] 0.078?0.233) to 0.031 (95% CI 0.008?0.073). The protective effect was ?79% (95% CI 40%?97%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.
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-----<cite cite="http://www.cdc.gov/eid/content/16/10/1562.htm"></cite>
[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Journal, full text: <cite cite="http://www.cdc.gov/eid/content/16/10/1562.htm">PPE and Oseltamivir Use | CDC EID</cite>. Abstract, edited.]
Volume 16, Number 10?October 2010
Research
Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Influenza A (H7N7) Epidemic, the Netherlands, 2003
Dennis E. te Beest
Comments to Author, Michiel van Boven, Marian E.H. Bos, Arjan Stegeman, and Marion P.G. Koopmans
Author affiliations: Utrecht University, Utrecht, the Netherlands (D.E. te Beest, M.E.H. Bos, A. Stegeman); and National Institute of Public Health and the Environment, Bilthoven, the Netherlands (D.E. te Beest, M. van Boven, M.P.G. Koopmans)
Abstract
We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95% confidence interval [CI] 0.078?0.233) to 0.031 (95% CI 0.008?0.073). The protective effect was ?79% (95% CI 40%?97%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.
-
-----<cite cite="http://www.cdc.gov/eid/content/16/10/1562.htm"></cite>