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Jpn J Infect Dis . Influenza A virus infection in domestic ferrets

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  • Jpn J Infect Dis . Influenza A virus infection in domestic ferrets

    Jpn J Infect Dis

    . 2021 Nov 30.
    doi: 10.7883/yoken.JJID.2021.745. Online ahead of print.
    Influenza A virus infection in domestic ferrets

    Yudai Kuroda 1 2 , Ai Okada 1 , Hiroshi Shimoda 1 , Yasutsugu Miwa 3 4 , Akiko Watamori 3 , Hiroho Ishida 4 , Shin Murakami 4 , Ayato Takada 5 , Taisuke Horimoto 4 , Ken Maeda 1 2

    AffiliationsFree article


    Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, we performed a serosurvey to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. We found a high positive rate of the H1 (24.1%) and H3 (5.2%) subtypes in pet ferrets by using an enzyme-linked immunosorbent assay for hemagglutinin proteins. The results were confirmed by the virus-neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory illness and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid for IAV infection from humans to ferrets, and vice versa.

    Keywords: Ferret; Influenza; Reverse zoonosis; Seroprevalence.