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Transbound Emerg Dis
. 2021 Jun 15.
doi: 10.1111/tbed.14190. Online ahead of print.
Pathogenicity and transmissibility of current H3N2 swine influenza virus in Southern China: A zoonotic potential
Yanan Yu 1 2 3 4 , Meihua Wu 1 2 3 4 , Xinxin Cui 1 2 3 4 , Fengxiang Xu 1 2 3 4 , Feng Wen 5 , Liangqi Pan 1 2 3 4 , Shuo Li 1 2 3 4 , Huapeng Sun 1 2 3 4 , Xuhui Zhu 1 2 3 4 , Jiate Lin 1 2 3 4 , Yaling Feng 1 2 3 4 , Mingliang Li 1 2 3 4 , Yang Liu 1 2 3 4 , Shaohua Yuan 1 2 3 4 , Ming Liao 1 2 3 4 , Hailiang Sun 1 2 3 4
Affiliations
- PMID: 34132051
- DOI: 10.1111/tbed.14190
Abstract
Swine are considered as "mixing vessels" of influenza A viruses and play an important role in the generation of novel influenza pandemics. In this study, we described that the H3N2 swine influenza (swH3N2) viruses currently circulating in pigs in Guangdong province carried six internal genes from 2009 pandemic H1N1 virus (pmd09), and their antigenicity was obviously different from that of current human H3N2 influenza viruses or recommended vaccine strains (A/Guangdong/1194/2019, A/Hong Kong/4801/2014). These swH3N2 viruses preferentially bonded to the human-like receptors, and efficiently replicated in human, canine and swine cells. In addition, the virus replicated in turbinate and trachea of guinea pigs, and efficiently transmitted among guinea pigs, and virus shedding last for 6 days post infection (dpi). The virus replicated in the respiratory tract of pigs, effectively transmitted among pigs, and virus shedding last until 9 dpi. Taken together, these current swH3N2 viruses might have the zoonotic potential. Strengthening surveillance and monitoring the pathogenicity of such swH3N2 viruses are urgently needed. This article is protected by copyright. All rights reserved.
Keywords: H3N2 influenza virus; antigenicity; pathogenicity; receptor binding feature; replication.